Sonderforschungsbereich 688




    1. Albert-Weissenberger C, Stetter C, Meuth SG, Göbel K, Bader M, Sirén AL, Kleinschnitz C. Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. J Cereb Blood Flow Metab. 2012 Sep;32(9):1747-56. doi: 10.1038/jcbfm.2012.62. Epub 2012 May 9. PubMed: 22569191  (TP A13)
    2. Boyanova, D., Nilla, S., Birschmann, I., Dandekar, T., and Dittrich, M. (2012). PlateletWeb: a systems biologic analysis of signaling networks in human platelets. Blood 119: e22-34. PubMed: 22123846 (TP A02)
    3. Burkhart, J., Vaudel, M., Gambaryan, S., Radau, S., Walter, U., Martens, L., Geiger, J., Sickmann, A., and Zahedi, R. (2012). The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood 120: 82. PubMed: 22123846 (TP A02)
    4. Chen, W., Gassner, B., Borner, S., Nikolaev, V.O., Schlegel, N., Waschke, J., Steinbronn, N., Strasser, R., and Kuhn, M. (2012). Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway. Cardiovasc Res 93: 141-151. PubMed: 22025581 (TP A04, A07)
    5. Deiss, K., Kisker, C., Lohse, M.J., and Lorenz, K. (2012). Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J Biol Chem 287: 23407-23417. PubMed: 22610096 (TP A16)
    6. Ertl, G., and Frantz, S. (2012). Adverse cardiac remodeling: phosphoinositide 3-kinase, another unique factor in a multifactorial condition. Circulation 126: 2175-2176. PubMed: 23019295 (TP A10)
    7. Gambaryan, S., Butt, E., Kobsar, A., Geiger, J., Rukoyatkina, N., Parnova, R., Nikolaev, V.O., and Walter, U. (2012a). The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells. Br J Pharmacol 167: 826-838. PubMed: 22612416http://22612416/ (TP A02)
    8. Gambaryan, S., Friebe, A., and Walter, U. (2012b). Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets? Blood 119: 5335-5336; author reply 5336-5337. PubMed: 22653960 (TP A02)
    9. Gupta, S., Braun, A., Morowski, M., Premsler, T., Bender, M., Nagy, Z., Sickmann, A., Hermanns, H.M., Bosl, M., and Nieswandt, B. (2012). CLP36 is a negative regulator of glycoprotein VI signaling in platelets. Circ Res 111: 1410-1420. PubMed: 22955732 (TP A01)
    10. Heisig, J., Weber, D., Englberger, E., Winkler, A., Kneitz, S., Sung, W.K., Wolf, E., Eilers, M., Wei, C.L., and Gessler, M. (2012). Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet 8: e1002728. PubMed: 22615585 (TP A16)
    11. Heydenreich, N., Nolte, M.W., Gob, E., Langhauser, F., Hofmeister, M., Kraft, P., Albert-Weissenberger, C., Brede, M., Varallyay, C., Gobel, K., et al. (2012). C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms. Stroke 43: 2457-2467. PubMed: 22744646 (TP A01, A13, B01)
    12. Hofmann, S., Vogtle, T., Bender, M., Rose-John, S., and Nieswandt, B. (2012a). The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets. J Thromb Haemost 10: 2581-2592. PubMed: 23025437 (TP A01)
    13. Hofmann, U., Beyersdorf, N., Weirather, J., Podolskaya, A., Bauersachs, J., Ertl, G., Kerkau, T., and Frantz, S. (2012b). Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation 125: 1652-1663. PubMed: 22388323 (TP A10)
    14. Hofmann, U., Bonz, A., Frantz, S., Hu, K., Waller, C., Roemer, K., Wolf, J., Gattenlohner, S., Bauersachs, J., and Ertl, G. (2012c). A collagen alpha2(I) mutation impairs healing after experimental myocardial infarction. Am J Pathol 180: 113-122. PubMed: 22067913 (TP A10)
    15. Langhauser, F., Gob, E., Kraft, P., Geis, C., Schmitt, J., Brede, M., Gobel, K., Helluy, X., Pham, M., Bendszus, M., et al. (2012). Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood 120: 4082-4092. PubMed: 22936662 (TP A01, B01, B04, Z02)
    16. Li, X., Samnick, S., Lapa, C., Israel, I., Buck, A.K., Kreissl, M.C., and Bauer, W. (2012). 68Ga-DOTATATE PET/CT for the detection of inflammation of large arteries: correlation with18F-FDG, calcium burden and risk factors. EJNMMI Res 2: 52. PubMed: 23016793 (TP A12, B01, B04, Z02)
    17. Michalska, M., Machtoub, L., Manthey, H.D., Bauer, E., Herold, V., Krohne, G., Lykowsky, G., Hildenbrand, M., Kampf, T., Jakob, P., et al. (2012). Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule-1-specific nanoparticles. Arterioscler Thromb Vasc Biol 32: 2350-2357. PubMed: 22879583 (TP B04, B05, A12, Z02)
    18. Nordbeck, P., Fidler, F., Friedrich, M.T., Weiss, I., Warmuth, M., Gensler, D., Herold, V., Geistert, W., Jakob, P.M., Ertl, G., et al. (2012). Reducing RF-related heating of cardiac pacemaker leads in MRI: implementation and experimental verification of practical design changes. Magn Reson Med 68: 1963-1972. PubMed: 22383393 (TP B04, Z02, B05).
    19. Thielmann, I., Stegner, D., Kraft, P., Hagedorn, I., Krohne, G., Kleinschnitz, C., Stoll, G., and Nieswandt, B. (2012). Redundant functions of phospholipases D1 and D2 in platelet alpha-granule release. J Thromb Haemost 10: 2361-2372. PubMed: 22974101 (TP A13, B01, A01)
    20. Tu, X., Chen, J., Lim, J., Karner, C.M., Lee, S.Y., Heisig, J., Wiese, C., Surendran, K., Kopan, R., Gessler, M., et al. (2012). Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet 8: e1002577. PubMed: 22457635 (TP A16)
    21. Vidal, M., Wieland, T., Lohse, M.J., and Lorenz, K. (2012). beta-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gbetagamma/Erk-dependent pathway. Cardiovasc Res 96: 255-264. PubMed: 22843704 (TP A17)
    22. Ziener, C.H., Kampf, T., Melkus, G., Jakob, P.M., Schlemmer, H.P., and Bauer, W.R. (2012a). Signal evolution in the local magnetic field of a capillary -- analogy to the damped driven harmonic oscillator. Magn Reson Imaging 30: 540-553. PubMed: 22305019 (TP B05, Z02)
    23. Ziener, C.H., Kampf, T., Reents, G., Schlemmer, H.P., and Bauer, W.R. (2012b). Spin dephasing in a magnetic dipole field. Phys Rev E Stat Nonlin Soft Matter Phys 85: 051908. PubMed: 23004789 (TP B05)
    24. Ziener, C.H., Rückl, M., Kampf, T., Bauer, W.R., and Schlemmer, H.P. (2012c). Mathieu functions for purely imaginary parameters. Journal of Computational and Applied Mathematics 236: 4513-4524. PubMed: (TP B05, Z02)
    25. Ziener, C.H., and Schlemmer, H.P. (2012). The inverse Laplace transform of the modified Lommel functions. Integral Transforms and Special Functions 24: 141-155. PubMed: (TP B05)


    1. De Meyer, S.F., Stoll, G., Wagner, D.D., and Kleinschnitz, C. (2012). von Willebrand factor: an emerging target in stroke therapy. Stroke 43: 599-606. PubMed: 22180250 (TP A13, B01)
    2. Dütting, S., Bender, M., and Nieswandt, B. (2012). Platelet GPVI: a target for antithrombotic therapy?! Trends Pharmacol Sci 33: 583-590. PubMed: 22901552 (TP A01)
    3. Dütting, S., and Nieswandt, B. (2012). Better safe than sorry: glycoprotein VI dimerization as a novel checkpoint and early biomarker of platelet activation. Arterioscler Thromb Vasc Biol 32: 552-553. PubMed: 22345591 (TP A01)
    4. Frantz, S., and Hofmann, U. (2012). Monocytes on the scar's edge. J Am Coll Cardiol 59: 164-165. PubMed: 22222081 (TP A10)
    5. Kleinschnitz C. and Plesnila N. (2012). Experimentelle Ansätze zur Therapie des ischämischen Schlaganfalls. Nervenarzt 83:1275-81. PubMed: 23015194 (TP A13)
    6. Kuhn, M. (2012). Endothelial actions of atrial and B-type natriuretic peptides. Br J Pharmacol 166: 522-531. PubMed: 22220582 (TP A7)
    7. Magnus, T., Wiendl, H., and Kleinschnitz, C. (2012). Immune mechanisms of stroke. Curr Opin Neurol 25: 334-340. PubMed: 22547104 (TP A13, B01)




    SFB 688 Mechanismen und Bildgebung von Zell-Zell- Wechselwirkungen im kardiovaskulären System
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