Sonderforschungsbereich 688



    1. Bauer, W. R. and Nadler, W. Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores. (2010). PLoS One 5:e15160. PubMed: 21179205 (TP B05)
    2. Bender, M., Eckly, A., Hartwig, J. H., Elvers, M., Pleines, I., Gupta, S., Krohne, G., Jeanclos, E., Gohla, A., Gurniak, C., Gachet, C., Witke, W. and Nieswandt, B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. (2010). Blood 116:1767-1775. PubMed: 20530287 (TP A01, A11)
    3. Bender, M., Hofmann, S., Stegner, D., Chalaris, A., Bosl, M., Braun, A., Scheller, J., Rose-John, S. and Nieswandt, B. Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. (2010). Blood 116:3347-3355. PubMed: 20644114 (TP A01)
    4. Bultmann, A., Li, Z., Wagner, S., Peluso, M., Schonberger, T., Weis, C., Konrad, I., Stellos, K., Massberg, S., Nieswandt, B., Gawaz, M., Ungerer, M. and Munch, G. Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin. (2010). J Mol Cell Cardiol 49:532-542. PubMed: 20430036 (TP A01)
    5. De Meyer, S. F., Schwarz, T., Deckmyn, H., Denis, C. V., Nieswandt, B., Stoll, G., Vanhoorelbeke, K. and Kleinschnitz, C. Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report. (2010). Arterioscler Thromb Vasc Biol 30:1949-1951. PubMed: 20616311 (TP A01, B01, A13)
    6. Defawe, O. D., Kim, S., Chen, L., Huang, D., Kenagy, R. D., Renne, T., Walter, U., Daum, G. and Clowes, A. W. VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen. (2010). J Cell Physiol 222:230-237. PubMed: 19798690 (TP A02)
    7. Dittrich, M., Strassberger, V., Fackler, M., Tas, P., Lewandrowski, U., Sickmann, A., Walter, U., Dandekar, T. and Birschmann, I. Characterization of a novel interaction between vasodilator-stimulated phosphoprotein and Abelson interactor 1 in human platelets: a concerted computational and experimental approach. (2010). Arterioscler Thromb Vasc Biol 30:843-850. PubMed: 20110575 (TP A02)
    8. Elvers, M., Pozgaj, R., Pleines, I., May, F., Kuijpers, M. J., Heemskerk, J. M., Yu, P. and Nieswandt, B. Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2. (2010). J Thromb Haemost 8:1353-1363. PubMed: 20230420 (TP A01)
    9. Elvers, M., Stegner, D., Hagedorn, I., Kleinschnitz, C., Braun, A., Kuijpers, M. E., Boesl, M., Chen, Q., Heemskerk, J. W., Stoll, G., Frohman, M. A. and Nieswandt, B. Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. (2010). Sci Signal 3:ra1. PubMed: 20051593 (TP A01, A13,B01)
    10. Erpenbeck, L., Nieswandt, B., Schon, M., Pozgajova, M. and Schon, M. P. Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. (2010). J Invest Dermatol 130:576-586. PubMed: 19727118 (TP A01)
    11. Gambaryan, S., Kobsar, A., Rukoyatkina, N., Herterich, S., Geiger, J., Smolenski, A., Lohmann, S. M. and Walter, U. Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. (2010). J Biol Chem 285:18352-18363. PubMed: 20356841 (TP A02)
    12. Geiger, J., Brandmann, T., Hubertus, K., Tjahjadi, B., Schinzel, R. and Walter, U. A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways. (2010). Anal Biochem PubMed: 20708596 (TP A02)
    13. Gilio, K., van Kruchten, R., Braun, A., Berna-Erro, A., Feijge, M. A., Stegner, D., van der Meijden, P. E., Kuijpers, M. J., Varga-Szabo, D., Heemskerk, J. W. and Nieswandt, B. Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. (2010). J Biol Chem 285:23629-23638. PubMed: 20519511 (TP A01)
    14. Hagedorn, I., Schmidbauer, S., Pleines, I., Kleinschnitz, C., Kronthaler, U., Stoll, G., Dickneite, G. and Nieswandt, B. Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding. (2010). Circulation 121:1510-1517. PubMed: 20308613 (TP A01, A13, B01)
    15. Hagedorn, I., Vogtle, T. and Nieswandt, B. Arterial thrombus formation. Novel mechanisms and targets Novel mechanisms and targets. (2010). Hamostaseologie 30:127-135. PubMed: 20680230 (TP A01)
    16. Hiller, K. H., Ruile, P., Kraus, G., Bauer, W. R. and Waller, C. Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats. (2010). Microvasc Res PubMed: 20570682 (TP B05, Z02)
    17. Hofmann, U., Bauersachs, J. and Frantz, S. Nothing but natural: targeting natural IgM in ischaemia/reperfusion injury. (2010). Cardiovasc Res 87:589-590. PubMed: 20573731 (TP A10)
    18. Kampf, T., Fischer, A., Basse-Lusebrink, T. C., Ladewig, G., Breuer, F., Stoll, G., Jakob, P. M. and Bauer, W. R. Application of compressed sensing to in vivo 3D (1)F CSI. (2010). J Magn Reson 207:262-273. PubMed: 20932790 (TP B05, B01, Z02)
    19. Kleinschnitz, C., Schwab, N., Kraft, P., Hagedorn, I., Dreykluft, A., Schwarz, T., Austinat, M., Nieswandt, B., Wiendl, H. and Stoll, G. Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. (2010). Blood 115:3835-3842. PubMed: 20215643 (TP A13, A01, B01)
    20. Klug, G., Kampf, T., Bloemer, S., Bremicker, J., Ziener, C. H., Heymer, A., Gbureck, U., Rommel, E., Noth, U., Schenk, W. A., Jakob, P. M. and Bauer, W. R. Intracellular and extracellular T(1) and T(2) relaxivities of magneto-optical nanoparticles at experimental high fields. (2010). Magn Reson Med PubMed: 20665826 (TP B05, B04, Z02)
    21. Kobsar, A. L., Koessler, J., Rajkovic, M. S., Brunner, K. P., Steigerwald, U. and Walter, U. Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system. (2010). Platelets 21:112-116. PubMed: 20085435 (TP A02)
    22. Kraft, P., Benz, P. M., Austinat, M., Brede, M. E., Schuh, K., Walter, U., Stoll, G. and Kleinschnitz, C. Deficiency of vasodilator-stimulated phosphoprotein (VASP) increases blood-brain-barrier damage and edema formation after ischemic stroke in mice. (2010). PLoS One 5:e15106. PubMed: 21151938 (TP A02, A13, B01)
    23. Kraft, P., Schwarz, T., Meijers, J. C., Stoll, G. and Kleinschnitz, C. Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice are susceptible to intracerebral thrombosis and ischemic stroke. (2010). PLoS One 5:e11658. PubMed: 20657835 (TP B01, A13)
    24. Kraft, P., Schwarz, T., Pochet, L., Stoll, G. and Kleinschnitz, C. COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke. (2010). Exp Transl Stroke Med 2:5. PubMed: 20298537 (TP B01, A13)
    25. Kramer, P., Helluy, X., Kampf, T., Lang, E. and Jakob, P. M. Flow-enhanced off-resonance saturation for remote detection of iron-based contrast agents. (2010). Magn Reson Med 63:1708-1715. PubMed: 20512876 (TP Z02)
    26. Parczyk, M., Herold, V., Klug, G., Bauer, W. R., Rommel, E. and Jakob, P. M. Regional in vivo transit time measurements of aortic pulse wave velocity in mice with high-field CMR at 17.6 Tesla. (2010). J Cardiovasc Magn Reson 12:72. PubMed: 21134260 (TP B04, B05, Z02)
    27. Petri, B., Broermann, A., Li, H., Khandoga, A. G., Zarbock, A., Krombach, F., Goerge, T., Schneider, S. W., Jones, C., Nieswandt, B., Wild, M. K. and Vestweber, D. von Willebrand factor promotes leukocyte extravasation. (2010). Blood 116:4712-4719. PubMed: 20716766 (TP A01)
    28. Pham, M., Helluy, X., Braeuninger, S., Jakob, P., Stoll, G., Kleinschnitz, C. and Bendszus, M. Outcome of experimental stroke in C57Bl/6 and Sv/129 mice assessed by multimodal ultra-high field MRI. (2010). Exp Transl Stroke Med 2:6. PubMed: 20230638 (TP A13, B01, Z02)
    29. Pham, M., Kleinschnitz, C., Helluy, X., Bartsch, A. J., Austinat, M., Behr, V. C., Renne, T., Nieswandt, B., Stoll, G. and Bendszus, M. Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI. (2010). Neuroimage 49:2907-2914. PubMed: 19958838 (TP A13, A01, B01)
    30. Pleines, I., Eckly, A., Elvers, M., Hagedorn, I., Eliautou, S., Bender, M., Wu, X., Lanza, F., Gachet, C., Brakebusch, C. and Nieswandt, B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. (2010). Blood 115:3364-3373. PubMed: 20139097 (TP A01, B01)
    31. Raslan, F., Schwarz, T., Meuth, S. G., Austinat, M., Bader, M., Renne, T., Roosen, K., Stoll, G., Siren, A. L. and Kleinschnitz, C. Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. (2010). J Cereb Blood Flow Metab 30:1477-1486. PubMed: 20197781 (TP A13, B01)
    32. Schuhmann, M. K., Stegner, D., Berna-Erro, A., Bittner, S., Braun, A., Kleinschnitz, C., Stoll, G., Wiendl, H., Meuth, S. G. and Nieswandt, B. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. (2010). J Immunol 184:1536-1542. PubMed: 20028655 (TP A13, B01, A01)
    33. Spindler, V., Vielmuth, F., Schmidt, E., Rubenstein, D. S. and Waschke, J. Protective endogenous cyclic adenosine 5'-monophosphate signaling triggered by pemphigus autoantibodies. (2010). J Immunol 185:6831-6838. PubMed: 21037102 (TP A04)
    34. Wiese, C., Heisig, J. and Gessler, M. Hey bHLH factors in cardiovascular development. (2010). Pediatr Cardiol 31:363-370. PubMed: 20033145 (TP A16)
    35. Ziener, C. H., Kampf, T., Jakob, P. M. and Bauer, W. R. Diffusion effects on the CPMG relaxation rate in a dipolar field. (2010). J Magn Reson 202:38-42. PubMed: 19853483 (TP B05, Z02)


    1. Nieswandt, B. and Stoll, G. The smaller, the better: VWF in stroke. (2010). Blood 115:1477-1478. PubMed: 20185592 (TP A01, B01)
    2. Schlegel, N. and Waschke, J. Vasodilator-stimulated phosphoprotein: crucial for activation of Rac1 in endothelial barrier maintenance. (2010). Cardiovasc Res 87:1-3. PubMed: 20308204 (TP A04)
    3. Spindler, V., Schlegel, N. and Waschke, J. Role of GTPases in control of microvascular permeability. (2010). Cardiovasc Res 87:243-253. PubMed: 20299335 (TP A04)
    4. Stoll, G., Kleinschnitz, C. and Nieswandt, B. The role of glycoprotein Ibalpha and von Willebrand factor interaction in stroke development. (2010). Hamostaseologie 30:136-138. PubMed: 20680228 (TP B01, TP A13, TP A01)
    5. Stoll, G., Kleinschnitz, C. and Nieswandt, B. Combating innate inflammation: a new paradigm for acute treatment of stroke? (2010). Ann N Y Acad Sci 1207:149-154. PubMed: 20955438 (TP B01, A01, A13)

    SFB 688 Mechanismen und Bildgebung von Zell-Zell- Wechselwirkungen im kardiovaskulären System
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