Deutsch Intern
    Sonderforschungsbereich 688



    1. Bauer, W. R. and Nadler, W. Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores. (2010). PLoS One5:e15160. PubMed: 21179205(TP B05)
    2. Bender, M., Eckly, A., Hartwig, J. H., Elvers, M., Pleines, I., Gupta, S., Krohne, G., Jeanclos, E., Gohla, A., Gurniak, C., Gachet, C., Witke, W. and Nieswandt, B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. (2010). Blood116:1767-1775. PubMed: 20530287(TP A01, A11)
    3. Bender, M., Hofmann, S., Stegner, D., Chalaris, A., Bosl, M., Braun, A., Scheller, J., Rose-John, S. and Nieswandt, B. Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. (2010). Blood116:3347-3355. PubMed: 20644114(TP A01)
    4. Bultmann, A., Li, Z., Wagner, S., Peluso, M., Schonberger, T., Weis, C., Konrad, I., Stellos, K., Massberg, S., Nieswandt, B., Gawaz, M., Ungerer, M. and Munch, G. Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin. (2010). J Mol Cell Cardiol49:532-542. PubMed: 20430036(TP A01)
    5. De Meyer, S. F., Schwarz, T., Deckmyn, H., Denis, C. V., Nieswandt, B., Stoll, G., Vanhoorelbeke, K. and Kleinschnitz, C. Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report. (2010). Arterioscler Thromb Vasc Biol30:1949-1951. PubMed: 20616311(TP A01, B01, A13)
    6. Defawe, O. D., Kim, S., Chen, L., Huang, D., Kenagy, R. D., Renne, T., Walter, U., Daum, G. and Clowes, A. W. VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen. (2010). J Cell Physiol222:230-237. PubMed: 19798690(TP A02)
    7. Dittrich, M., Strassberger, V., Fackler, M., Tas, P., Lewandrowski, U., Sickmann, A., Walter, U., Dandekar, T. and Birschmann, I. Characterization of a novel interaction between vasodilator-stimulated phosphoprotein and Abelson interactor 1 in human platelets: a concerted computational and experimental approach. (2010). Arterioscler Thromb Vasc Biol30:843-850. PubMed: 20110575(TP A02)
    8. Elvers, M., Pozgaj, R., Pleines, I., May, F., Kuijpers, M. J., Heemskerk, J. M., Yu, P. and Nieswandt, B. Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2. (2010). J Thromb Haemost8:1353-1363. PubMed: 20230420(TP A01)
    9. Elvers, M., Stegner, D., Hagedorn, I., Kleinschnitz, C., Braun, A., Kuijpers, M. E., Boesl, M., Chen, Q., Heemskerk, J. W., Stoll, G., Frohman, M. A. and Nieswandt, B. Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. (2010). Sci Signal3:ra1. PubMed: 20051593(TP A01, A13,B01)
    10. Erpenbeck, L., Nieswandt, B., Schon, M., Pozgajova, M. and Schon, M. P. Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. (2010). J Invest Dermatol130:576-586. PubMed: 19727118(TP A01)
    11. Gambaryan, S., Kobsar, A., Rukoyatkina, N., Herterich, S., Geiger, J., Smolenski, A., Lohmann, S. M. and Walter, U. Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. (2010). J Biol Chem285:18352-18363. PubMed: 20356841(TP A02)
    12. Geiger, J., Brandmann, T., Hubertus, K., Tjahjadi, B., Schinzel, R. and Walter, U. A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways. (2010). Anal Biochem PubMed: 20708596(TP A02)
    13. Gilio, K., van Kruchten, R., Braun, A., Berna-Erro, A., Feijge, M. A., Stegner, D., van der Meijden, P. E., Kuijpers, M. J., Varga-Szabo, D., Heemskerk, J. W. and Nieswandt, B. Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. (2010). J Biol Chem285:23629-23638. PubMed: 20519511(TP A01)
    14. Hagedorn, I., Schmidbauer, S., Pleines, I., Kleinschnitz, C., Kronthaler, U., Stoll, G., Dickneite, G. and Nieswandt, B. Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding. (2010). Circulation121:1510-1517. PubMed: 20308613(TP A01, A13, B01)
    15. Hagedorn, I., Vogtle, T. and Nieswandt, B. Arterial thrombus formation. Novel mechanisms and targets Novel mechanisms and targets. (2010). Hamostaseologie30:127-135. PubMed: 20680230(TP A01)
    16. Hiller, K. H., Ruile, P., Kraus, G., Bauer, W. R. and Waller, C. Tissue ACE inhibition improves microcirculation in remote myocardium after coronary stenosis: MR imaging study in rats. (2010). Microvasc Res PubMed: 20570682(TP B05, Z02)
    17. Hofmann, U., Bauersachs, J. and Frantz, S. Nothing but natural: targeting natural IgM in ischaemia/reperfusion injury. (2010). Cardiovasc Res87:589-590. PubMed: 20573731(TP A10)
    18. Kampf, T., Fischer, A., Basse-Lusebrink, T. C., Ladewig, G., Breuer, F., Stoll, G., Jakob, P. M. and Bauer, W. R. Application of compressed sensing to in vivo 3D (1)F CSI. (2010). J Magn Reson207:262-273. PubMed: 20932790(TP B05, B01, Z02)
    19. Kleinschnitz, C., Schwab, N., Kraft, P., Hagedorn, I., Dreykluft, A., Schwarz, T., Austinat, M., Nieswandt, B., Wiendl, H. and Stoll, G. Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. (2010). Blood115:3835-3842. PubMed: 20215643(TP A13, A01, B01)
    20. Klug, G., Kampf, T., Bloemer, S., Bremicker, J., Ziener, C. H., Heymer, A., Gbureck, U., Rommel, E., Noth, U., Schenk, W. A., Jakob, P. M. and Bauer, W. R. Intracellular and extracellular T(1) and T(2) relaxivities of magneto-optical nanoparticles at experimental high fields. (2010). Magn Reson Med PubMed: 20665826(TP B05, B04, Z02)
    21. Kobsar, A. L., Koessler, J., Rajkovic, M. S., Brunner, K. P., Steigerwald, U. and Walter, U. Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system. (2010). Platelets21:112-116. PubMed: 20085435(TP A02)
    22. Kraft, P., Benz, P. M., Austinat, M., Brede, M. E., Schuh, K., Walter, U., Stoll, G. and Kleinschnitz, C. Deficiency of vasodilator-stimulated phosphoprotein (VASP) increases blood-brain-barrier damage and edema formation after ischemic stroke in mice. (2010). PLoS One5:e15106. PubMed: 21151938(TP A02, A13, B01)
    23. Kraft, P., Schwarz, T., Meijers, J. C., Stoll, G. and Kleinschnitz, C. Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice are susceptible to intracerebral thrombosis and ischemic stroke. (2010). PLoS One5:e11658. PubMed: 20657835(TP B01, A13)
    24. Kraft, P., Schwarz, T., Pochet, L., Stoll, G. and Kleinschnitz, C. COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke. (2010). Exp Transl Stroke Med2:5. PubMed: 20298537(TP B01, A13)
    25. Kramer, P., Helluy, X., Kampf, T., Lang, E. and Jakob, P. M. Flow-enhanced off-resonance saturation for remote detection of iron-based contrast agents. (2010). Magn Reson Med63:1708-1715. PubMed: 20512876(TP Z02)
    26. Parczyk, M., Herold, V., Klug, G., Bauer, W. R., Rommel, E. and Jakob, P. M. Regional in vivo transit time measurements of aortic pulse wave velocity in mice with high-field CMR at 17.6 Tesla. (2010). J Cardiovasc Magn Reson12:72. PubMed: 21134260(TP B04, B05, Z02)
    27. Petri, B., Broermann, A., Li, H., Khandoga, A. G., Zarbock, A., Krombach, F., Goerge, T., Schneider, S. W., Jones, C., Nieswandt, B., Wild, M. K. and Vestweber, D. von Willebrand factor promotes leukocyte extravasation. (2010). Blood116:4712-4719. PubMed: 20716766(TP A01)
    28. Pham, M., Helluy, X., Braeuninger, S., Jakob, P., Stoll, G., Kleinschnitz, C. and Bendszus, M. Outcome of experimental stroke in C57Bl/6 and Sv/129 mice assessed by multimodal ultra-high field MRI. (2010). Exp Transl Stroke Med2:6. PubMed: 20230638(TP A13, B01, Z02)
    29. Pham, M., Kleinschnitz, C., Helluy, X., Bartsch, A. J., Austinat, M., Behr, V. C., Renne, T., Nieswandt, B., Stoll, G. and Bendszus, M. Enhanced cortical reperfusion protects coagulation factor XII-deficient mice from ischemic stroke as revealed by high-field MRI. (2010). Neuroimage49:2907-2914. PubMed: 19958838(TP A13, A01, B01)
    30. Pleines, I., Eckly, A., Elvers, M., Hagedorn, I., Eliautou, S., Bender, M., Wu, X., Lanza, F., Gachet, C., Brakebusch, C. and Nieswandt, B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. (2010). Blood115:3364-3373. PubMed: 20139097(TP A01, B01)
    31. Raslan, F., Schwarz, T., Meuth, S. G., Austinat, M., Bader, M., Renne, T., Roosen, K., Stoll, G., Siren, A. L. and Kleinschnitz, C. Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation. (2010). J Cereb Blood Flow Metab30:1477-1486. PubMed: 20197781(TP A13, B01)
    32. Schuhmann, M. K., Stegner, D., Berna-Erro, A., Bittner, S., Braun, A., Kleinschnitz, C., Stoll, G., Wiendl, H., Meuth, S. G. and Nieswandt, B. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. (2010). J Immunol184:1536-1542. PubMed: 20028655(TP A13, B01, A01)
    33. Spindler, V., Vielmuth, F., Schmidt, E., Rubenstein, D. S. and Waschke, J. Protective endogenous cyclic adenosine 5'-monophosphate signaling triggered by pemphigus autoantibodies. (2010). J Immunol185:6831-6838. PubMed: 21037102(TP A04)
    34. Wiese, C., Heisig, J. and Gessler, M. Hey bHLH factors in cardiovascular development. (2010). Pediatr Cardiol31:363-370. PubMed: 20033145(TP A16)
    35. Ziener, C. H., Kampf, T., Jakob, P. M. and Bauer, W. R. Diffusion effects on the CPMG relaxation rate in a dipolar field. (2010). J Magn Reson202:38-42. PubMed: 19853483(TP B05, Z02)


    1. Nieswandt, B. and Stoll, G. The smaller, the better: VWF in stroke. (2010). Blood115:1477-1478. PubMed: 20185592(TP A01, B01)
    2. Schlegel, N. and Waschke, J. Vasodilator-stimulated phosphoprotein: crucial for activation of Rac1 in endothelial barrier maintenance. (2010). Cardiovasc Res87:1-3. PubMed: 20308204(TP A04)
    3. Spindler, V., Schlegel, N. and Waschke, J. Role of GTPases in control of microvascular permeability. (2010). Cardiovasc Res87:243-253. PubMed: 20299335(TP A04)
    4. Stoll, G., Kleinschnitz, C. and Nieswandt, B. The role of glycoprotein Ibalpha and von Willebrand factor interaction in stroke development. (2010). Hamostaseologie30:136-138. PubMed: 20680228(TP B01, TP A13, TP A01)
    5. Stoll, G., Kleinschnitz, C. and Nieswandt, B. Combating innate inflammation: a new paradigm for acute treatment of stroke? (2010). Ann N Y Acad Sci1207:149-154. PubMed: 20955438(TP B01, A01, A13)

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