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    Sonderforschungsbereich 688

    Inflammation and cardiac damage – role of CD4+-T-cells after myocardial infarction

    G. Ertl, U. Hofmann, T. Kerkau

    Summary

    CD4+ T-cells improve healing and remodeling after myocardial infarction. Our results suggest, that activation of T-cells after myocardial infarction is antigen dependent. Thus, we want to test whether recognition of antigens released after myocardial injury induces a protective T-cell response. On the other side, we could show that protective T-cell effects are mediated via regulatory T-cells. Therefore, we want to test clinical relevant therapeutic strategies to activate regulatory T-cells to improve healing in our murine myocardial infarction model.

    Healing after myocardial infarction is significantly impaired in Cd4-/- and MhcII-/- mice (Ladewig staining, collagen stains blue) [Ref. Hofmann U, Beyersdorf N, Weirather J, Podolskaya A, Bauersachs J, Ertl G, Kerkau T, Frantz S (2012). Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation 125, 1652-1663]

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